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TYLENOL® Cold + Flu Severe For Day And Night Time

Relief Of Fever, Pain, Cough & Congestion

Convenient caplets to relieve painful cold and flu symptoms like coughing, congestion, and sore throat both day and night.

In September, 2023, The Nonprescription Drugs Advisory Committee of the Food and Drug Administration reviewed efficacy data available for orally administered phenylephrine (PE) as a nasal decongestant. Read the FDA’s statement about this review here.

Product Details

Daytime Uses

  • for the temporary relief of the following cold/flu symptoms:

    • minor aches and pains

    • headache

    • sore throat

    • nasal congestion

    • cough

  • helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive

  • temporarily reduces fever

Nighttime Uses

  • for the temporary relief of the following cold/flu symptoms:

    • minor aches and pains

    • headache

    • sore throat

    • nasal congestion

    • cough

    • sinus congestion and pressure

    • sneezing and runny nose

  • helps clear nasal passages

  • relieves cough to help you sleep

  • temporarily reduces fever

Daytime

Active Ingredients (in each caplet)

Purpose

Acetaminophen 325 mg

Pain reliever/fever reducer

Dextromethorphan HBr 10 mg

Cough suppressant

Guaifenesin 200 mg

Expectorant

Phenylephrine HCI 5 mg

Nasal decongestant

Inactive Ingredients

carnauba wax, croscarmellose sodium, D&C yellow no. 10 aluminum lake, flavor, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, sucralose, titanium dioxide

Nighttime

Active Ingredients (in each caplet)

Purpose

Acetaminophen 325 mg

Pain reliever/fever reducer

Chlorpheniramine maleate 2 mg

Antihistamine

Dextromethorphan HBr 10 mg

Cough suppressant

Phenylephrine HCI 5 mg

Nasal decongestant

Inactive ingredients

anhydrous citric acid, carnauba wax, FD&C blue no. 1 aluminum lake, flavor, hypromellose, magnesium stearate, microcrystalline cellulose, modified starch, polyethylene glycol, polysorbate 80, potassium sorbate, powdered cellulose, pregelatinized starch, sodium benzoate, sodium citrate dihydrate, sodium starch glycolate, sucralose, titanium dioxide

Do not take more than directed.

See overdose warning

Age

Dosage

adults and children 12 years and older

• take 2 caplets every 4 hours

• swallow whole; do not crush, chew or dissolve

• do not take more than 10 caplets in 24 hours

children under 12 years

ask a doctor

Daytime Warnings

Liver warning: This product contains acetaminophen. The maximum daily dose of this product is 10 caplets (3,250 mg acetaminophen) in 24 hours. Severe liver damage may occur if you take

  • more than 4,000 mg of acetaminophen in 24 hours

  • with other drugs containing acetaminophen

  • 3 or more alcoholic drinks every day while using this product

Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include:

  • skin reddening

  • blisters

  • rash

If a skin reaction occurs, stop use and seek medical help right away.

Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.

Do not use

  • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.

  • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

  • if you have ever had an allergic reaction to this product or any of its ingredients

Ask a doctor before use if you have

  • liver disease

  • heart disease

  • high blood pressure

  • thyroid disease

  • diabetes

  • trouble urinating due to an enlarged prostate gland

  • persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis or emphysema

  • cough that occurs with too much phlegm (mucus)

Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin

When using this product do not exceed recommended dose

Stop use and ask a doctor if

  • nervousness, dizziness, or sleeplessness occur

  • pain, nasal congestion or cough gets worse or lasts more than 7 days

  • fever gets worse or lasts more than 3 days

  • redness or swelling is present

  • new symptoms occur

  • cough comes back or occurs with rash or headache that lasts

These could be signs of a serious condition.

If pregnant or breastfeeding, ask a health professional before use.

Keep out of reach of children.

Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222).Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

Nighttime Warnings

Liver warning: This product contains acetaminophen. The maximum daily dose of this product is 10 caplets (3,250 mg acetaminophen) in 24 hours. Severe liver damage may occur if you take

  • more than 4,000 mg of acetaminophen in 24 hours

  • with other drugs containing acetaminophen

  • 3 or more alcoholic drinks every day while using this product

Allergy alert: acetaminophen may cause severe skin reactions. Symptoms may include:

  • skin reddening

  • blisters

  • rash

If a skin reaction occurs, stop use and seek medical help right away.

Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.

Do not use

  • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.

  • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

  • if you have ever had an allergic reaction to this product or any of its ingredients

Ask a doctor before use if you have

  • liver disease

  • heart disease

  • high blood pressure

  • thyroid disease

  • diabetes

  • trouble urinating due to an enlarged prostate gland

  • persistent or chronic cough such as occurs with smoking, asthma or emphysema

  • cough that occurs with too much phlegm (mucus)

  • a breathing problem such as emphysema or chronic bronchitis

  • glaucoma

Ask a doctor or pharmacist before use if you are

  • taking the blood thinning drug warfarin

  • taking sedatives or tranquilizers

When using this product

  • do not exceed recommended dose

  • excitability may occur, especially in children

  • marked drowsiness may occur

  • alcohol, sedatives and tranquilizers may increase drowsiness

  • avoid alcoholic drinks

  • be careful when driving a motor vehicle or operating machinery

Stop use and ask a doctor if

  • nervousness, dizziness, or sleeplessness occur

  • pain, nasal congestion or cough gets worse or lasts more than 7 days

  • fever gets worse or lasts more than 3 days

  • redness or swelling is present

  • new symptoms occur

  • cough comes back or occurs with rash or headache that lasts

These could be signs of a serious condition.

If pregnant or breastfeeding, ask a health professional before use.

Keep out of reach of children.

Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

This website contains current product information and may differ from the information on the product packaging you may have. If you have any questions, please contact the Consumer Care Center at 1-877-895-3665.

  • store between 20 - 25°C (68 - 77°F)

This website contains current product information and may differ from the information on the product packaging you may have.

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