Acetaminophen is the pain reliever of choice for most patients taking medications for high blood pressure as well as for those patients taking low-dose aspirin to prevent heart attacks and strokes. Acetaminophen does not interfere with aspirin's ability to protect against heart attack or stroke.

Acetaminophen, the medicine in Tylenol, is not an NSAID or a COX-2 inhibitor.

McNeil Consumer Healthcare has studied acetaminophen in over 1,500 patients who received maximum recommended daily doses (4 grams daily) of acetaminophen for up to one year. No cardiovascular deaths, heart attacks, or strokes have occurred among these patients receiving acetaminophen during the study period. In addition, published studies of acetaminophen used for as long as two years have not demonstrated an increased risk of these cardiovascular events.

Acetaminophen, the medicine in Tylenol, is the most widely used OTC pain reliever in the U.S. and is considered the preferred pain reliever for large segments of the population, including the elderly and pediatric patients. In fact, for over 50 years, when used as directed, Tylenol remains the safest pain reliever consumers can take. Results of approximately 500 clinical trials underscore the safety profile of acetaminophen.